Technical Data
B2555-01H
Bonzo, NT (C-X-C Chemokine Receptor Type 6, CXC-R6, CXCR-6, CDw186, G-protein Coupled Receptor STRL33, G-protein Coupled Receptor Bonzo, CD186, CXCR6, STRL33, TYMSTR)
Description:
Human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) require co-receptors, in addition to CD4, to infect target cells. Some G protein-coupled receptors including CCR5, CXCR4, CCR3, and CCR2b in the chemokine receptor family have been identified as HIV co-receptors. An orphan G protein-coupled receptor was recently cloned and designated Bonzo, STRL33 and TYMSTR, and identified as HIV and SIV co-receptor. Bonzo/STRL33 is used by SIV, HIV-2 and HIV-1. The messenger RNA of Bonzo/STRL33 is expressed in lymphoid tissues and activated peripheral blood lymphocytes.

Applications:
Suitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested.

Recommended Dilution:
Western Blot: 1ug/ml
Immunohistochemistry: 20ug/ml
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
PabIgGAffinity Purified
SizeStorageShippingSourceHost
50ug-20CBlue IceHumanRabbit
Concentration:
~0.1mg/ml
Immunogen:
Synthetic peptide corresponding to aa fnear the N-terminus of human Bonzo/STRL33.
Purity:
Purified by immunoaffinity chromatography.
Form
Supplied as a liquid in PBS, 0.05% sodium azide.
Specificity:
Recognizes human Bonzo.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1. Alkhatib, G. et al. Nature 388, 238 (1997). 2. Deng, HK. et al. Nature 388, 296 (1997). 3. Liao, F. et al. J Exp Med 185, 2015 (1997). 4. Loetscher, M. et al. Curr Biol 7, 652 (1997).