Technical Data
Calcitonin (Katacalcin) is a 32 amino acids poly-peptide hormone that is commonly expressed in the parafollicular or C cells in the thyroid gland. It is also synthesized in a wide variety of other tissues, including the lung and intestinal tract (1). Calcitonin is a potent plasma calcium-lowering peptide; it decreases the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones. Calcitonin staining is used in the identification of C cell proliferative abnormalities, such as C cell hyperplasia and invasive tumors (2). Staining for calcitonin may be used for the identification of a spectrum of C cell proliferative abnormalities ranging from C cell hyperplasia to invasive tumors (e.g. medullary thyroid carcinomas). Calcitonin activitiy might be exhibited in amyloid deposits within the tumor.

Suitable for use in Immunohistochemistry. Other applications not tested.

Recommended Dilution:
Immunohistochemistry: 1:200
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
100ul-20CBlue IceHumanMouse
Not Determined
Synthetic peptide corresponding to aa1-32 of human Calcitonin.
Supplied as a liquid, 0.05% BSA, 0.1% sodium azide.
Recognizes human calcitonin. Species Crossreactivity: rat
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1. Copp DH, Nature 27:193:381-382, 1962. 2. Mortensen LS et al. Basic Clin Pharmacol Toxicol. 97(1):22-28, 2005.