Technical Data
Calphostin C (Antibiotic UCN-1028 C, UCN 1028 C)
Biochemicals Storage: +4CShipping: Blue Ice
Calphostin C is a perylenequinione isolated from the fungus, Cladosporium cladosporioides. It is a potent and specific inhibitor of protein kinase C with inhibition being light dependent. Also shown to inhibit cell proliferation and induce apoptosis in vitro.

Purity: >95% by HPLC

Solubility: Soluble in ethanol, methanol, DMF or DMSO

CAS Number:

Molecular Formula:

Molecular Weight:
Source: Cladosporium cladosporioides

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
1. Growth inhibition induced by Ro 31-8220 and calphostin C in human glioblastoma cell lines is
associated with apoptosis and inhibition of CDC2 kinase. Begemann M. et al. Anticancer Res. 1998, 18,
2. Inhibition of protein kinase C by calphostin C is light-dependent. Bruns R.F. et al. Biochem. Biophys.
Res. Commun. 1991, 176, 288.
3. Calphostins (UCN-1028), novel and specific inhibitors of protein kinase C. I. Fermentation, isolation,
physico-chemical properties and biological activities. Kobayashi E. et al. J. Antibiot. 1989, 42, 1470.
4. Calphostins, novel and specific inhibitors of protein kinase C. II. Chemical structures. Kobayashi E. et al.
J. Antibiot. 1989, 42, 1475.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.