Technical Data
C2096-64E
CTNNB1 (Catenin beta-1, Beta-catenin, CTNNB, OK/SW-cl.35, PRO2286)
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Technical Data |
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C2096-64E |
CTNNB1 (Catenin beta-1, Beta-catenin, CTNNB, OK/SW-cl.35, PRO2286) |
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Description: Beta-catenin is an adherens junction protein, which mediates cell-cell adhesion, cell-cell communication and contributes to cytoskeletal integrity. It is similar to the product of the Drosophila segment polarity gene armadillo. Like armadillo, beta-catenin is part of the E cadherin multiprotein complex that regulates pattern formation at several stages of embryogenesis. In addition beta-catenin is involved in wound healing and tumor cell metastasis. Beta-catenin is part of the Wnt signaling cascade. It interacts with Tcf and Lef to activate gene transcription and regulates cell growth. Beta-catenin accumulation has been observed in various cancers, especially in colorectal tumors and hepatoblastoma. Beta-catenin-mediated transcription is down regulated when the protein binds to the tumor suppressor protein APC. Applications: Suitable for use in Flow Cytometry, Immunocytochemistry, Western Blot, Immunoprecipitation and Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry (Formalin fixed paraffin embedded): 10ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. |
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