Description:
Cathepsin B is a cysteine endopeptidase which is synthesized as a 40kD inactive glycoprotein which is processed into the mature form. Cathepsin B is widely expressed by various tissues.
Applications:
Suitable for use in Immunohistochemistry (paraffin-embedded sections). Other applications not tested.
Recommended Dilution:
Optimal dilutions to be determined by the researcher.
Storage and Stability:
May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
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| Type | Isotype | Clone | Grade |
|---|
| Mab | IgG2b | 8J538 | |
|
| Size | | Storage | Shipping | Source | Host |
|---|
| 500ul | | -20°C | Blue Ice | Human | Mouse |
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| Concentration: |
| As reported |
| Immunogen: |
| Recombinant human cathepsin B. |
| Purity: |
| Tissue culture supernatant |
| Form |
| PBS with 0.09% sodium azide |
| Specificity: |
| This antibody is specific for Cathepsin B, a lysosomal protease expressed in a wide range of tissues, including liver, skeletal muscle, and heart. Species Crossreactivity: Crossreacts with Human. |
|
| Intended for research use only. Not for use in human, therapeutic, or diagnostic applications. |
This product has been used in:Ravikumar B et al. Raised intracellular glucose concentrations reduce aggregation and cell death caused by mutant huntingtin exon 1 by decreasing mTOR phosphorylation and inducing autophagy. Hum Mol Genet 12:985-94 (2003). Strojnik T et al. Cathepsin B immunohistochemical staining in tumor and endothelial cells is a new prognostic factor for survival in patients with brain tumors. Clin Cancer Res 5:559-67 (1999).
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