Cathepsin B is a cysteine endopeptidase which is synthesized as a 40kD inactive glycoprotein which is processed into the mature form. Cathepsin B is widely expressed by various tissues.
Suitable for use in Immunohistochemistry (paraffin-embedded sections). Other applications not tested.
Optimal dilutions to be determined by the researcher.
Storage and Stability:
May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
| Not determined|
|Recombinant human cathepsin B.|
|Tissue culture supernatant|
|PBS with 0.09% sodium azide|
|This antibody is specific for Cathepsin B, a lysosomal protease expressed in a wide range of tissues, including liver, skeletal muscle, and heart. Species Crossreactivity: Crossreacts with Human. |
|Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.|
This product has been used in:Ravikumar B et al. Raised intracellular glucose concentrations reduce aggregation and cell death caused by mutant huntingtin exon 1 by decreasing mTOR phosphorylation and inducing autophagy. Hum Mol Genet 12:985-94 (2003). <12700167> Strojnik T et al. Cathepsin B immunohistochemical staining in tumor and endothelial cells is a new prognostic factor for survival in patients with brain tumors. Clin Cancer Res 5:559-67 (1999). <10100707>|