Technical Data
C2099-66J
CCR2 (NT) (CD192, C-C chemokine receptor type 2, C-C CKR-2, Monocyte chemoattractant protein 1 receptor, MCP-1-R, CMKBR2)
Description:
CCR2 (C-C chemokine receptor type 2 is, a transmembrane glycoprotein and member of the G-protein coupled receptor 1 family, which acts as a receptor for the chemokines MCP-1 (monocyte chemoattractant protein 1), MCP-3 and MCP-4. Interaction between CD192 and MCP-1 initiates chemotactic responses, through an increase in intracellular calcium levels. CD192 acts as a co-receptor with CD4 for HIV1 infection, and variations in CD192 are associated with relative resistance to HIV1.

Applications:
Suitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested.

Recommended Dilution:
ELISA: 1:60,000
Western Blotting: 1:1000
Immunohistochemistry (paraffin): 1:200
Optimal dilutions to be determined by the researcher.

Positive Control:
Spleen

Storage and Stability:
May be stored at 4C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20C. Aliquots are stable for at least 12 months at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
TypeIsotypeCloneGrade
PabIgGAffinity Purified
SizeStorageShippingSourceHost
100ug-20CBlue IceHumanGoat
Concentration:
~1mg/ml
Immunogen:
Synthetic peptide CGEEVTTFFDYDYGAPCHKFDVKQ corresponding to aa17-39 within the N-terminal region of human CCR2.
Purity:
Purified by immunoaffinity chromatography.
Form
Supplied as a liquid in 10mM KHPO4, 140mM sodium chloride, pH7.2, 0.09% sodium azide, 0.1% BSA.
Specificity:
Recognizes an epitope within the N-terminal region of human CCR2.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.