Technical Data
C2100-20
CCR11 (Chemokine Receptor 11, CKRB)
Description:
Chemokine receptors are specialized proteins that function at the surface of cells, and enable chemokines to trigger internal cellular processes. Chemokines and their receptors play a pivotal role in lymphocyte trafficking, recruiting and recirculation. Chemokines act through seven transmembrane G protein-coupled receptors. The chemokine system is increasingly recognized to play an important role in lymphocyte biology.

CCR11 is a G protein-coupled, seven-transmembrane receptor protein that plays a role in the chemotaxis and trafficking of leukocytes. Showing similar binding affinities as does CCR2 and CCR10 (1,2), CCR11 has been shown to specifically bind the MCP- (monocyte chemoattractant protein) family of chemokines, including MCP-4, MCP-2, and MCP-1. It was also shown to bind eotaxin (3). Though CCR11 shares functional similarity to CCR2 because it recognizes members of the MCP family, CCR11 has a distinct expression pattern (3).

Application(s):
ELISA: 1:75,000
Western Blotting: 1:1,000
Immunohistochemistry: 1:250

Storage and Stability:
May be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
TypeIsotypeCloneGrade
PabIgGAffinity Purified
SizeStorageShippingSourceHost
100ug-20°CBlue IceHumanGoat
Concentration:
As reported
Immunogen:
Synthetic peptide EQNQSTDYYYEENEMNGTYDYSQYELIC corresponding to a 4-31 of human CCR11.
Purity:
Purified by immunoaffinity chromatography.
Form
Supplied as a liquid in PBS, pH 7.2, 1mg/ml BSA, 0.1% sodium azide before the addition of 40% glycerol.
Specificity:
Peptide sequence is < 50% identical to other human chemokine receptors in this region. Will cross-react to mouse CCR11. Crossreacts with human and mouse.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1. Bonini, J.A. et al. Cloning, expression, and chromosomal mapping of a novel human CC-chemokine receptor (CCR10) that displays high-affinity binding for MCP-1 and MCP-3. DNA Cell Biol. 16(10): 1249–56 (1997).
2. Berkhout T.A. et al. Cloning, in vitro expression, and functional characterization of a novel human CC chemokine of the monocyte chemotactic protein (MCP) family (MCP-4) that binds and signals through the CC chemokine receptor 2B. J Biol Chem. 272(26): 16404–13 (1997).
3. Schweickart, V.L. et al. CCR11 is a functional receptor for the monocyte chemoattractant protein family of chemokines. J Biol Chem. 275(13): 9550–6 (2000).