Technical Data
C2566-01L
CDCP1 (CUB Domain-containing Protein 1, Membrane Glycoprotein gp140, Subtractive Immunization M Plus HEp3-associated 135kD Protein, SIMA135, Transmembrane and Associated with Src Kinases, CD318, TRASK, UNQ2486/PRO5773) (APC)
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Technical Data |
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C2566-01L |
CDCP1 (CUB Domain-containing Protein 1, Membrane Glycoprotein gp140, Subtractive Immunization M Plus HEp3-associated 135kD Protein, SIMA135, Transmembrane and Associated with Src Kinases, CD318, TRASK, UNQ2486/PRO5773) (APC) |
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Description: CDCP1, also known as SIMA135, is a novel 140kD type I transmembrane glycoprotein with three CUB protein-protein interaction domains in its 635aa extracellular region. The 148aa cytoplasmic region contains canonical phosphorylation sites for Src kinase family members and binding sites for SH3 domains. By alternative splicing, a secreted 310aa residue form of CDCP1 also exists. The amino-terminal region of ~265aa of the type I membrane CDCP1 can also be proteolytically cleaved. CDCP1 is found on the surface of epithelial and bone marrow- derived stem cells. The extracellular region of human CDCP1 shares 84% aa identity with that of the mouse protein. Applications: Suitable for use Flow Cytometry. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Absorption: 620-650nm Emission: 660-670nm Storage and Stability: May be stored at 4°C before opening. DO NOT FREEZE! Stable at 4°C as an undiluted liquid. Dilute only prior to immediate use. Stable for 12 months. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer. APC is light sensitive. |
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