Technical Data
Chapsyn 110 (PSD93, Discs Large Homolog 2, DLG2, Channel-associated Protein of SynapsesChapsyn 110 (PSD93, Discs Large Homolog 2, DLG2, Channel-associated Protein of Synapses)
Chapsyn-110, is a part of the membrane-associated putative guanylate kinase (MAGUK) family. It binds directly to the NMDA receptor, and Shaker K+ channel subunits, and is 70-80% identical to PSD-95/SAP90 and SAP97 (1). It associated tightly with the postsynaptic density I brain, and mediates the clustering of both NMDA recpetors and K+ channels in heterologous cells. The
encoded protein forms a heterodimer with PSD-95 that may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins (1, 2).

Suitable for use in Western Blot, Immunoprecipitation and Immunohistochemistry. Other applications not tested.

Recommended Dilution:
Western Blot:1-10ug/ml
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
MabIgG110F694Affinity Purified
100ug-20CBlue IceRatMouse
Fusion protein aa 1-852 of rat Chapsyn-110 (accession number Q63622).
Purified by Protein G affinity chromatography.
Supplied as a liquid in PBS, pH7.4, 50% glycerol and 0.09% sodium azide.
Recognizes rat Chapsyn-110. Species Crossreactivity: human (weak). No cross-reactivity against other.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1. Kim E., et al. (1996) Neuron.17:103-113. 2. Godreau D., Neyroud N., Vranckx R. and Hatem S. (2004) Med Sci (Paris). 20(1):84-88.