Technical Data
C3550-05
Chapsyn 110 (PSD93, Discs Large Homolog 2, DLG2, Channel-associated Protein of SynapsesChapsyn 110 (PSD93, Discs Large Homolog 2, DLG2, Channel-associated Protein of Synapses)
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Technical Data |
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C3550-05 |
Chapsyn 110 (PSD93, Discs Large Homolog 2, DLG2, Channel-associated Protein of SynapsesChapsyn 110 (PSD93, Discs Large Homolog 2, DLG2, Channel-associated Protein of Synapses) |
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Description: Chapsyn-110, is a part of the membrane-associated putative guanylate kinase (MAGUK) family. It binds directly to the NMDA receptor, and Shaker K+ channel subunits, and is 70-80% identical to PSD-95/SAP90 and SAP97 (1). It associated tightly with the postsynaptic density I brain, and mediates the clustering of both NMDA recpetors and K+ channels in heterologous cells. The encoded protein forms a heterodimer with PSD-95 that may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins (1, 2). Applications: Suitable for use in Western Blot, Immunoprecipitation and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot:1-10ug/ml Immunohistochemistry:0.1-1ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. |
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