Technical Data
C5042-09A
CCK4, NT (Tyrosine-protein Kinase-like 7, Colon Carcinoma Kinase-4, CCK-4, Protein-tyrosine Kinase 7, PTK7)
Description:
PTK7 may function as a cell adhesion molecule. Although it belongs to the insulin receptor subfamily of Tyr protein kinases, it likely lacks the catalytic activity of a tyrosine kinase. It may be connected to the pathophysiology of colon carcinomas and/or may represent a tumor progression marker. This Type I membrane protein is highly expressed in lung, liver, pancreas, kidney, placenta and melanocytes, and it is weakly expressed in thyroid gland, ovary, brain, heart and skeletal muscle, and not in colon. Expression is also detected in erythroleukemia cells.

Applications:
Suitable for use in ELISA and Immunohistochemistry. Other applications not tested.

Recommended Dilution:
ELISA: 1:1,000
Immunohistochemistry: 1:50-1:100
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
PabIgGAffinity Purified
SizeStorageShippingSourceHost
200ul-20CBlue IceHumanRabbit
Concentration:
As reported
Immunogen:
Synthetic peptide selected from the N-terminal region of human PTK7 (KLH).
Purity:
Purified by Protein G affinity chromatography.
Form
Supplied as a liquid in PBS, 0.09% sodium azide.
Specificity:
Recognizes human PTK7.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1.Zhang, H., et al., Nat. Biotechnol. 21(6):660-666 (2003). 2.Park, S.K., et al., J. Biochem. 119(2):235-239 (1996). 3.Mossie, K., et al., Oncogene 11(10):2179-2184 (1995).