Technical Data
C5071-30
Chrysomycin A (Chrysomycin V, Virenomycin V, Albacarcin V)
500ug
Biochemicals Storage: +4CShipping: Blue Ice
Chrysomycin A is the major analogue in a complex of C-glycoside antitumor actives isolated from Streptomyces. Chrysomycin A, with a vinyl group in the 8-position, is the most potent analogue of the complex, which is thought to act as an inhibitor of the catalytic activity of human topoisomerase II. Chrysomyin A has a potent antibacterial, antifungal, antiviral and antitumor profile. More recent research on related metabolites, the gilvocarcins, suggests that chrysomycins may act as photoactivated, crosslinkers of DNA to histones.

Purity: >99% by HPLC

Solubility: Soluble in DMF or DMSO. Moderately soluble in methanol or ethanol.

Related to: Chrysomycin B, Gilvocarcin M, Gilvocarcin V, O-Deacetyl-ravidomycin

CAS Number:
82196-88-1

Molecular Formula:
C28H28O9

Molecular Weight:
508.52
Source: Streptomyces sp.

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
1. Histone H3 and heat shock protein GRP78 are selectively cross-linked to DNA by photoactivated
gilvocarcin V in human fibroblasts. Matsumoto A. et al. Cancer Res. 2000, 60, 3921.
2. Chrysomycin derivative compounds and use as antitumor agents. US Patent 6,030,951, 2000.
3. Biochemical characterisation of elsamicin and other coumarin-related antitumour agents as potent
inhibitors of human topoisomerase II. Lorico A. et al. Eur. J. Cancer. 1993, 29A, 1985.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.