Technical Data
C7505-15B
Cochlioquinone B
500ug
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Technical Data |
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C7505-15B |
Cochlioquinone B |
500ug |
| Biochemicals | Storage: +4°CShipping: Blue Ice |
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Cochlioquinone B, the minor component of a bioactive pigment isolated from Bipolaris leersia, is an NADH-ubiquinone reductase inhibitor and a phytotoxic agent inhibiting root growth. It is closely related to Cochlioquinone A that inhibits diacylglycerol acyltransferase and exhibits anti-angiogenic and nematocidal activity. Cochlioquinones have been recently shown to be antagonists of the human chemokine receptor CCR5 in human immunodeficiency virus type 1 (HIV-1). Purity: >99% by HPLC Solubility: Soluble in ethanol, methanol, DMF or DMSO. Related to: Cochlioquinone A CAS Number: 32450-26-3 Molecular Formula: C28H40O6 Molecular Weight: 472.61 |
Source: Bipolaris leersia Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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1. Cochlioquinones and epi-cochlioquinones: antagonists of the human chemokine receptor CCR5 from Bipolaris brizae and Stachybotrys chartarum. Yoganathan K. et al. J. Antibiot. 2004, 57, 59. 2. Cochlioquinone A1, a new anti-angiogenic agent from Bipolaris zeicola. Jung H.J. et al. Bioorg. Med. Chem. 2003, 11, 4743. 3. Inhibitory activity of diacylglycerol acyltransferase by cochlioquinones A and A1. Lee H.B. et al. J. Antibiot. 2003, 56, 967. 4. Phytotoxic compounds cochlioquinones are inhibitors of mitochondrial NADH-ubiquinone reductase. Lim C.-H. et al. J. Pesticide Sci. 1996, 21, 213.
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