Technical Data
Cochlioquinone B
Biochemicals Storage: +4CShipping: Blue Ice
Cochlioquinone B, the minor component of a bioactive pigment isolated from Bipolaris leersia, is an NADH-ubiquinone reductase inhibitor and a phytotoxic agent inhibiting root growth. It is closely related to Cochlioquinone A that inhibits diacylglycerol acyltransferase and exhibits anti-angiogenic and nematocidal activity. Cochlioquinones have been recently shown to be antagonists of the human chemokine receptor CCR5 in human immunodeficiency virus type 1 (HIV-1).

Purity: >99% by HPLC

Solubility: Soluble in ethanol, methanol, DMF or DMSO.

Related to: Cochlioquinone A

CAS Number:

Molecular Formula:

Molecular Weight:
Source: Bipolaris leersia

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
1. Cochlioquinones and epi-cochlioquinones: antagonists of the human chemokine receptor CCR5 from
Bipolaris brizae and Stachybotrys chartarum. Yoganathan K. et al. J. Antibiot. 2004, 57, 59.
2. Cochlioquinone A1, a new anti-angiogenic agent from Bipolaris zeicola. Jung H.J. et al. Bioorg. Med.
Chem. 2003, 11, 4743.
3. Inhibitory activity of diacylglycerol acyltransferase by cochlioquinones A and A1. Lee H.B. et al. J.
Antibiot. 2003, 56, 967.
4. Phytotoxic compounds cochlioquinones are inhibitors of mitochondrial NADH-ubiquinone reductase.
Lim C.-H. et al. J. Pesticide Sci. 1996, 21, 213.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.