Technical Data
C8452-72H
Cyclin A2, ID (Cyclin-A, CCNA2, CCN1, CCNA)
Description:
Regulated progression through the cell cycle requires sequential expression of a family of proteins called cyclins. Upon their induction, cyclins form complexes with specific cyclin-dependent kinases (CDKs), creating active holoenzymes that phosphorylate target proteins required for cell-cycle progression. Cyclin A2 (ccna2) is involved in cell cycle control in the S and M phases. One study demonstrated that Cyclin A2 is necessary for visual system development and function. Within humans, Cyclin A is complexed with CDK2 and is a crucial element during S and G2/M phases of the cell cycle, although the mechanism of regulation is not well understood.

Applications:
Suitable for use in ELISA. Other applications not tested.

Recommended Dilution:
ELISA: 1:5000-1:20,000
Optimal dilutions to be determined by the researcher.

Control Peptide: C8452-72Q

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
PabIgGAffinity Purified
SizeStorageShippingSourceHost
250ul-20CBlue IceZebrafishRabbit
Concentration:
Not determined
Immunogen:
Synthetic peptide corresponding to the intermediate region of zebrafish Cyclin A2.
Purity:
Purified by immunoaffinity chromatography.
Form
Supplied as a liquid in 40mM MOPS, pH 7.5, 0.1% BSA, 0.1% sodium azide, 50% glycerol.
Specificity:
Recognizes zebrafish Cyclin A2.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1. Duffy, KT et al (2005) Nucleic Acids Res. 33(15): 4914-4921. 2. Gross, JM et al (2005) Genetics 170(1): 245-261. 3. Tsang, WY et al (2007) J. Cell Biol. 178: 621-633