Technical Data
C9095-19W3
CYP19A1, ID (Cytochrome P450 19A1, CYPXIX, Estrogen Synthetase, P-450AROM, Aromatase, Cytochrome P-450AROM, ARO1, CYAR, CYP19)
Description:
CYP19A1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids.This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis, three successive hydroxylations of the A ring of androgens. Mutations in this gene can result in either increased or decreased aromatase activity; the associated phenotypes suggest that estrogen functions both as a sex steroid hormone and in growth or differentiation.

Applications:
Suitable for use in Western Blot. Other applications not tested.

Recommended Dilutions:
Western Blot: 1:1000
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
PabIgGPurified
SizeStorageShippingSourceHost
200ul-20CBlue IceHumanRabbit
Concentration:
As reported
Immunogen:
Synthetic peptide corresponding to aa221-253 from the central region of CYP19A1, conjugated to KLH.
Purity:
Purified by ammonium sulfate precipitation
Form
Supplied as a liquid in PBS, 0.09% sodium azide.
Specificity:
Recognizes human CYP19A1 at ~58kD.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1.Ikeda,S.,Am. J. Gastroenterol. 103(6), 1476-1487 (2008). 2.Dos Santos,(er) DNA Cell Biol. (2008) In press. 3.Nelson,Pharmacogenetics 14(1), 1-18 (2004).