Technical Data
D3570-04
Ivermectin (Dihydroavermectin B1a, Ivermectin B1a, 22, 23-Dihydro-avermectin B1a )
1mg
Biochemicals Storage: 4C/-20CShipping: Blue Ice
Ivermectin B1a is the major component (>80%) of the commercial anthelmintic, ivermectin. Members of the avermectin/milbemycin anthelmintic class exert their anthelmintic effects by binding to glutamate-gated chloride channels expressed on nematode neurones and pharyngeal muscle cells. The avermectins and milbemycins are also potent insecticides. The individual 25-sec-butyl (B1a) and 25-iso-propyl (B1b) components of ivermectin have received little separate study.

Soluble in ethanol, methanol, DMF or DMSO.

CAS Number:
70161-11-4

Molecular Formula:
C48H74O14

Molecular Weight:
875.1
Source: Streptomyces sp.
Purity: >95% by HPLC
Form: White solid

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
1. Ivermectin, a new broad-spectrum antiparasitic agent. Chabala J.C. et al. J. Med. Chem. 1980, 23, 1134. 2. Glutamate-gated chloride channels and the mode of action of the avermectin/milbemycin anthelmintics. Wolstenholme A.J & Rogers A.T. Parasitology, 2005, 131, S85. 3. Avermectin/milbemycin resistance in trichostrongylid nematodes. Gill J.H. & Lacey E. Int J. Parasitol. 1998, 28, 863. 4. Ivermectin: a potent new antiparasitic agent. Campbell W.C. et al., Science, 1983, 221, 823.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.