Technical Data
D3765
Dinactin (Antibiotic AKD 1C, Antibiotic S 3466A)
1mg
Biochemicals Storage: +4CShipping: Blue Ice
Dinactin is a member of the macrotetrolide complex produced by a range of Streptomyces species. It is a monovalent cation ionophore with high selectivity for ammonium and potassium. Dinactin inhibited T-cell proliferation induced by IL-2 and cytokine production at nanomolar levels for IL-2, IL-4, IL-5 and interferon- . Dinactin has not previously been available for intensive investigation.

Purity: >95% by HPLC

Solubility: Soluble in ethyl acetate or DMSO, moderately in soluble ethanol or methanol

Related to: Monactin, Trinactin

CAS Number:
20261-85-2

Molecular Formula:
C42H68O12

Molecular Weight:
765
Source: Streptomyces sp.

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
1. Effects of cyclosporin A and dinactin on T-cell proliferation, interleukin-5 production, and murine
pulmonary inflammation. Umland S.P. et al. Am. J. Respir. Cell Mol. Biol. 1999, 20, 481.
2. Immunosuppressive effects of polynactins (tetranactin, trinactin and dinactin) on experimental
autoimmune uveoretinitis in rats. Tanouchi Y. et al. Jpn. J. Ophthalmol. 1987, 31, 218.
3. Antibiotics as tools for metabolic studies. VI. Damped oscillatory swelling of mitochondria induced by
nonactin, monactin, dinactin, and trinactin. Graven S.N. et al. Biochemistry 1966, 5, 1735.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.