Doxorubicin, Hydrochloride (Adriacin, Adriblastina, Adriamycin, Caelyx)
|Biochemicals||Storage: -20°CShipping: RT|
The hydrochloride salt of doxorubicin, an anthracycline antibiotic with antineoplastic activity. Doxorubicin, isolated from the bacterium Streptomyces peucetius var. caesius, is the hydroxylated congener of daunorubicin. Doxorubicin intercalates between base pairs in the DNA helix, thereby preventing DNA replication and ultimately inhibiting protein synthesis. Additionally, doxorubicin inhibits topoisomerase II which results in an increased and stabilized cleavable enzyme-DNA linked complex during DNA replication and subsequently prevents the ligation of the nucleotide strand after double-strand breakage. Doxorubicin also forms oxygen free radicals resulting in cytotoxicity secondary to lipid peroxidation of cell membrane lipids; the formation of oxygen free radicals also contributes to the toxicity of the anthracycline antibiotics, namely the cardiac and cutaneous vascular effects.
Melting Point: 198-203ºC
Solubility: Methanol: Water (1:1), Water
Storage and Stability:
May be stored at RT for short-term only. Long-term storage is recommended at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Hygroscopic and light sensitive.
Form: Supplied as an orange-red solid
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Toxicity and Hazards:
Due to the potential danger associated with the use of some of United States Biological biochemicals, all products should be handled by qualified personnel only, trained in laboratory procedures, and familiar with potential hazards. Information is not available on the possible hazards of many experimental compounds. The absence of a warning must not be interpreted as indication of safety. The ultimate responsibility for the proper handling of any and all chemicals lies with the user. All goods sold by United States Biological carry the condition that liability for any injury, loss or damage whatsoever to persons or real property resulting from the handling of the said goods lies with the user. Acceptance of our goods binds the customer to these terms.
1. Adriamycin (14-hydroxydaunomycin), a novel antitumor antibiotic. Arcamone F. et al., Tet. Letters 1969,
2. Interference by doxorubicin with DNA unwinding in MCF-7 breast tumor cells. Fornari F.L. et al., Mol.
Pharmacology 1994, 45, 649.
3. Effect of Adriamycin on DNA, RNA, and protein synthesis in cell-free systems and intact cells. Momarier
R. et al., Cancer Research 1976, 36, 2891.