Technical Data
D9641-01D
DVL3 (Dishevelled-3, Dsh Homolog 3, Segment Polarity Protein Dishevelled Homolog DVL-3, KIAA0208)
Description:
Dishevelled-3 (DVL-3) is a cytoplasmic phoshoprotein that regulates cell proliferation, acting as a transducer molecule for developmental processes including segmentation and neuroblast specification in Drosophila. It is known to play a crucial role in WNT canonical signaling pathway and has been shown to be a connecting link between the Notch-WNT crosstalk. The structural and evolutionary characteristics suggest that mutations at their loci may be involved in neural and heart development defects.

Applications:
Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested.

Recommended Dilution:
Western Blot: 1-3ug/ml
Immunohistochemistry (formalin fixed paraffin embedded): 5ug/ml
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
PabIgGAffinity Purified
SizeStorageShippingSourceHost
100ug-20CBlue IceHumanRabbit
Concentration:
~0.5mg/ml
Immunogen:
Synthetic peptide corresponding to aa560-610 of human DVL-3.
Purity:
Purified by Protein A affinity chromatography.
Form
Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide.
Specificity:
Recognizes human DVL-3. Species Crossreactivity: chimpanzee, canine, equine, monkey, mouse, rat, rhesus monkey. Species sequence homology: chicken.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1. Klingensmith, J. et al. Genes Dev. 8:118-130 (1994). 2. Sun, T.Q. et al. Nat. Cell Biol. 3:628-636 (2001). 3. Pizzuti, A. et al. Hum. Mol. Genet. 5:953-958 (1996).