Technical Data
E2286-05A
HERV, ID (HERV-W_7q21.2 Provirus Ancestral Env Polyprotein, Envelope Polyprotein gPr73, HERV-7q Envelope Protein, HERV-W Envelope Protein, Syncytin, Syncytin-1, Enverin, Env-W, ERVWE1)
Description:
Many different human endogenous retrovirus (HERV) families are expressed in normal placental tissue at high levels, suggesting that HERVs are functionally important in reproduction. The protein, also known as syncytin, is expressed in the placental syncytiotrophoblast and is involved in fusion of the cytotrophoblast cells to form the syncytial layer of the placenta. This protein has the characteristics of a typical retroviral envelope protein, including a furin cleavage site that separates the surface (SU) and transmembrane (TM) proteins which form a heterodimer.

Applications:
Suitable for use in ELISA and Western Blot. Other applications not tested.

Recommended Dilution:
ELISA: 1:1,000
Western Blot: 1:50-1:100
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
PabIgGAffinity Purified
SizeStorageShippingSourceHost
200ul-20CBlue IceHumanRabbit
Concentration:
As reported
Immunogen:
Synthetic peptide selected from the Center region of human ERVWE1 (KLH).
Purity:
Purified by Protein G affinity chromatography.
Form
Supplied as a liquid in PBS, 0.09% sodium azide.
Specificity:
Recognizes human ERVWE1.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1. Oluwole,S.O., Amyotroph Lateral Scler 8(2), 67-72 (2007). 2. Gong,R., Cell. Physiol. Biochem. 20(5), 517-526 (2007). 3. Antony,J.M., AIDS Res. Hum. Retroviruses 22(12), 1253-1259 (2006).