Technical Data
Endothelin (EDN 1, EDN 2, EDN 3, EDN1, EDN2, EDN3, Endothelin 1, Endothelin 1 precursor, Endothelin 2, Endothelin 2 precursor, Endothelin 3, Endothelin 3 precursor)
Endothelins (ET) show potent constrictor activity in vascular and non-vascular smooth muscle. This family of 21-amino acid peptides exists in at least three isoforms, ET-1, ET-2, and ET-3, and is produced in endothelial and epithelial cells. ET's can mediate biological effects in cells and tissues, and have been shown to bind to an ET receptor in the lung, kidney, heart and liver.

Suitable for use inImmunoradiometric (IRMA) Assays and Immunohistochemistry. Other applications not tested.

Recommended Dilution:
Immunohistochemistry: Frozen
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4C for short-term only. For long-term storage, aliquot and store at -20C. Aliquots are stable for at least 12 months at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
100ug4C (-20C Glycerol)Blue IceHumanRat
Not determined.
Recombinant fragment corresponding to human Endothelin (BSA). Cellular Localization: Secreted.
Supplied as a liquid in PBS. pH 7.4, 10mM sodium azide before the addition of glycerol to 40%.
Recognizes C-terminal region of all human endothelins (amino acid residues 15-21) when used as a capture antibody in IRMA assays. Does not crossreact with big endothelin.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.