Technical Data
Endothelin, pan
Endothelins (ET) show potent constrictor activity in vascular and non-vascular smooth muscle. This family of 21-amino acid peptides exists in at least three isoforms- ET-1, ET-2, and ET-3, and is produced in endothelial and epithelial cells. ET's can mediate biological effects in cells and tissues, and have been shown to bind to an ET receptor in the lung, kidney, heart, and liver.

Suitable for use in ELISA. Other applications not tested.

Recommended Dilution:
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20C. Aliquots are stable for at least 12 months at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
100ul-20CBlue IceHumanMouse
Not determined
Synthetic peptide: CHLDIIW, corresponding to amino acids 15-21 of pan Endothelin.
Supplied as a liquid in PBS, pH 7.2.
Detects endothelin (ET)-1, ET-2 and ET-3. This antibody shows no crossreactivity with the peptides ET(15-20) and ET(15-22). Species Crossreactivity: Crossreacts with Human.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1. Federation of American Societies for Experimental Biology. 75th Annual Meeting. Atlanta, Georgia, April 21-25, 1991. Part I. Abstracts. FASEB J 5:A450 (1991). 2. Deng Y et al. (1992) J Biochem (Tokyo) 111:346-51 . 3. Rubanyi GM & Botelho LH (1991) Endothelins. FASEB J 5:2713-20.