Technical Data
EphA4 (Ephrin Receptor Eph A4, Ephrin Receptor EphA4, Ephrin Type A Receptor 4, EPH Receptor A4, Eph A4, EPH-like Kinase 8, EK8, HEK8, Receptor Protein Tyrosine Kinase HEK8, SEK, TYRO1 Protein Tyrosine Kinase, Tyrosine Protein Kinase Receptor SEK, Tyrosin
EphA4 is ubiquitously expressed in the body, and is thought to play a role in a number of different developmental pathways, including the corticospinal tract formation, hindbrain pattern formation and regulating the structure of synaptic connections. EphA4 may also act as a locomotor central pattern generator.

Suitable for use in Immunohistochemistry (paraffin). Other applications not tested.

Recommended Dilution:
Immunohistochemistry (paraffin): 5-10ug/ml
Requires antigen retrieval using heat treatment for 20 minutes prior to staining of paraffin sections. Optimal dilutions to be determined by the researcher.

Positive Control: Glomerulus

Storage and Stability:
May be stored at 4C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile 40-50% glycerol, aliquot and store at -20C. Aliquots are stable for at least 12 months at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
PabIgGAffinity Purified
50ug-20CBlue IceHumanRabbit
Synthetic peptide corresponding to internal domain of human EphA4.
Purified by immunoaffinity chromatography.
Supplied as a liquid in PBS, pH 7.7, 0.09% sodium azide.
Recognizes human EphA4.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1. Kullander, K. et al. (2001) Kinase-dependent and kinase-independent functions of EphA4 receptors in major axon tract formation in vivo. Neuron 29: 73-84. 2. Murai, K. K. et al. (2003) Control of hippocampal dendritic spine morphology through ephrin-A3/EphA4 signaling. Nat. Neurosci. 6: 153-160. 3. Theil, T. et al. (1998) Segmental expression of the EphA4 (Sek-1) receptor tyrosine kinase in the hindbrain is under direct transcriptional control of Krox-20. Development. 125: 443-452.