Technical Data
F4165-02B
FIAF (Fasting-induced Adipose Factor, Angiopoietin-like Protein 4, Angiopoietin-like 4, ANGPTL 4, ANGPTL4, Angiopoitein-related Protein 4, ARP4, Hepatic Fibrinogen Angiopoietin-related Protein, HFARP, NG27, NL2, Peroxisome Proliferator-activated Receptor
Description:
The fasting-induced adipose factor (FIAF, ANGPTL4, PGAR, HFARP) was previously identified as a novel adipocytokine that was up-regulated by fasting, by peroxisome proliferators- activated receptor agonists, and by hypoxia. FIAF and other adipocytokines including resistin, adiponectin, acylationstimulating protein, plasminogen activator inhibitor-1, rennin angiotensin system, metallothioneins and tumor growth factor-b have been implicated in a variety of different processes, ranging from blood pressure control to lipid metabolism and insulin senziting. It has been tempting to attribute many of the clinical abnormalities associated with obesity from insulin resistance to altered secretion of particular adipocytokines.

Applications:
Suitable for use in ELISA. Other applications not tested.

Recommended Dilution:
ELISA: 1:32,000
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
PabIgGAffinity Purified
SizeStorageShippingSourceHost
100ug-20CBlue IceMouseGoat
Concentration:
~0.5mg/ml
Immunogen:
Synthetic peptide corresponding to C-HLDNGVDKTSRGKK, from the internal region of ANGPTL4 (NP_065606.1).
Purity:
Purified by affinity chromatography.
Form
Supplied as a liquid in Tris saline, 0.02% sodium azide, pH7.3, 0.5% BSA.
Specificity:
Recognizes ANGPTL4. Sequence Homology: mouse, rat.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1. Lichtenstein L, Berbe JF, van Dijk SJ, van Dijk KW, Bensadoun A, Kema IP, Voshol PJ, Mller M, Rensen PC, Kersten S. Angptl4 upregulates cholesterol synthesis in liver via inhibition of LPL- and HL-dependent hepatic cholesterol uptake. Arterioscler Thromb Vasc Biol. 2007 Nov;27(11):2420-7. Epub 2007 Aug 30. PMID: 17761937