Technical Data
G2024-50
Geldanamycin (Streptomyces hygroscopicus) 98+%
1mg
5mg
25mg
5mg
25mg
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Technical Data |
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G2024-50 |
Geldanamycin (Streptomyces hygroscopicus) 98+% |
1mg 5mg 25mg |
| Biochemicals | Storage: -20°CShipping: RT |
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Geldanamycin is benzoquinone ansamycin antibiotic isolated from Streptomyces hygroscopicus. A potent antitumor 1 and potent inhibitor of p60c-crc tyrosine kinase, erb B2,2 EGF receptor tyrosine kinase and non-receptor tyrosine kinases. 3, Geldanamycin binds specifically and inhibits the chaperone protein Hsp90.2 Geldanamycin acts by binding to the 90kD heat-shock protein (Hsp90) essential to maintain the conformation, stability, activity and cellular localization of several key oncogenic proteins such as ERBB2, C-RAF, CDK4, AKT/PKB, steroid hormone receptors, mutant p53, HIF-1alpha, survivin and telomerase hTERT. Related to: Antibiotic TAN 420C, Antibiotic TAN 420E, Herbimycin A, Herbimycin B Solubility: 1mg/ml in DMSO Impurities: Major Impurities: 1% Total Impurities: 2% Heavy Metals: 0.02% Storage and Stability: Store at -20°C. Stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Protect from light. CAS Number: 30562-34-6 Molecular Formula: C29H40N2O9 Molecular Weight: 560.6 |
Purity: 98% Form: Supplied as a yellow, lyophilized powder. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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11. Supko, J.G. et al. (1995) Cancer Chemother.Pharmacol. 36, 305. 2. Chavany, C. et al. (1996) J. Biol. Chem. 271, 4974. 3. Whitesell, L. et al. (1996) Mol. Endocrinol. 10, 705.
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