Technical Data
G2033-27
GFR alpha2 (GDNF Family Receptor alpha 2, GDNF Receptor alpha-2, GDNFR-alpha-2, GFR-alpha-2, GFRA2, GDNF Receptor beta, GDNFR-beta, GDNFRB, Neurturin Receptor alpha, NRTNR-alpha, NTNR-alpha, NTNRA, RET Ligand 2, RETL2, TGF-beta-related Neurotrophic Factor
Description:
GFRa-2, also known as NTNRa, GDNFRb, Ret ligand 2 (RETL2) or TGFb-related neurotrophic factor receptor 2 (TNR2) binds NTN and mediates activation of RET receptor tyrosine kinase by both NTN and GDNF. GDNF (glial cell line-derived neurotrophic factor) is a potent survival factor for central and peripheral neurons. Physiological responses to GDNF require the presence of a novel glycosylphophadidylinositol linked protein GDNFRa.

Applications:
Suitable for use in Western Blot. Other applications not tested.

Recommended Dilution:
Western Blot: 1-2ug/ml
Optimal dilutions to be determined by the researcher.

Positive Control:
HeLa

Storage and Stability:
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
PabIgGAffinity Purified
SizeStorageShippingSourceHost
100ug-20°CBlue IceHumanRabbit
Concentration:
As reported
Immunogen:
Synthetic peptide corresponding to aa377-391 of human GFRa-2/GDNFb/RETL2.
Purity:
Purified by Protein G affinity chromatography.
Form
Supplied as a liquid in PBS, 0.02% sodium azide.
Specificity:
Recognizes human GFRa-2/GDNFb/RETL2. Species Crossreactivity: mouse and rat.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1. Kotzbauer PT, Lampe PA, Heuckerothh RO, et al. Nature 384: 467-470 (1996). 2. Klein RD, Sherman D, Ho WH, Stone D, Bennet GL, et al. Nature 387: 717-721 (1997). 3. BujiBello A, Abu J, Pinon LG, Horton A, et al. Nature 387: 721-724 (1997). 4. Baloh RH, Tansey MG, Golden JP, Creedon DJ, et al. Neuron 18: 793-802 (1997).