Technical Data
G8123
Glutathione
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Technical Data |
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G8123 |
Glutathione |
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Description: Glutathione is a tripeptide (gama-glutamylcysteinylglycine) molecule found in most mammmalian cells. It functions in basic metabolic processes such as serving as a sulfydryl buffer to maintain redox within the cell, participating in the transport of amino acids and detoxifying hydrogen and organic peroxides. Glutathione depletion can inhibit Th-1 associated cytokine production and favors a Th-2 associated immune response. Glutathione deficiency has also been linked to decreased patient survival in HIV-infected individuals. Overexpression of apoptotic protein Bcl-2 causes relocalization of glutathione from the cytoplasm into the nucleus where glutathione is thought to alter the redox and block caspase activity. Applications: Suitable for use in Western Blot, ELISA and Immunoprecipitation. Other applications not tested. Recommended Dilutions: Western Blot: 1:1000. Under non-reducing conditions ELISA: 1:1000 Immunoprecipitation: 1:1000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. |
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