Technical Data
G9940-01
GP2 (Pancreatic Secretory Granule Membrane Major Glycoprotein GP2, Pancreatic Zymogen Granule Membrane Protein GP-2, ZAP75)
Description:
GP2 is a phosphatidylinositol-glycan-linked membrane protein released from the membrane of mature zymogen granules by an enzymatic mechanism. It is the major membrane protein in the pancreatic secretory granule of the exocrine pancreas and also a critical component in regulated membrane trafficking along the apical secretory pathway in pancreatic acinar cells The protein contains a 130aa containing domain, D8C, located between the N-terminal signal sequence and the zona pellucida (ZP) domain in the C-terminal half of the protein. The protein exists in two isoforms, the alpha and beta forms. The beta form lacks a 147aa domain that corresponds to the 25-171 region of the alpha form, suggesting that it is a product of an alternative splicing event. The gene encoding for human GP2 is localized in the chromosomal region 16p12.

Applications:
Suitable for use in ELISA. Other applications not tested.

Recommended Dilution:
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
PabIgGSerum
SizeStorageShippingSourceHost
100ul-20CBlue IceHumanRabbit
Concentration:
Not determined.
Immunogen:
Synthetic peptide corresponding to aa30-48 (QRGYGNPIEASSYGLDLDC) of human GP2.
Purity:
Serum
Form
Supplied as a liquid, 0.025% sodium azide, 50% glycerol.
Specificity:
Recognizes human GP2.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1. Fukuoka, S. et al. Proc. Natl. Acad. Sci. USA. 88:2898-2902 (1991). 2. Yang, H. et al. FEBS Lett. 578:236-238 (2004).