Technical Data
Heterochromatin Protein 1, beta (HP1-beta, HP1 beta, Chromobox Homolog 1, CBX1, CBX, Heterochromatin Protein p25 beta, HP1Hsbeta, HP1Hs-beta, M31, Modifier 1 Protein, MOD1, p25beta)
HP1Hsbeta is one of three mammalian HP1 homologues which localize to centromeric heterochromatin and are characterized by an amino-terminal chromodomain, hinge region and a carboxy-terminal chromoshadow domain. HP1Hsbeta is a component of both pericentric and telomeric heterochromatin and can directly associate with EMSY, TIF1 (transcriptional intermediary factor 1), LBR (lamin B receptor) and CHAF1A (chromatin assembly factor 1, subunit A) via the chromoshadow domain, and with tri-methylated histone H3 lysine 9 via the chromodomain.

Suitable for use in Western Blot. Other applications not tested.

Recommended Dilution:
Western Blot: 1:1000-1:5000
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
PabIgGAffinity Purified
50ug-20CBlue IceHumanGoat
Synthetic peptide corresponding to an epitope between amino acids 50-100 of human HP1Hsbeta (NP_006798.1).
Purified by immunoaffinity chromatography.
Supplied as a liquid in tris-citrate/phosphate, 0.09% sodium azide.
Recognizes human HP1Hsbeta (heterochromatin protein 1 homolog beta), a highly conserved nonhistone chromatin component and member of the HP1 family which are involved in heterochromatin formation, transcriptional activation and arrest, gene silencing and chromatin remodelling.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1. Lomberk, G. et al. (2006) The heterochromatin protein 1 family. Genome Biology 7: 228-235.