		Technical Data
H7022-90	HOXA9 (Homeobox Protein Hox-A9, Homeobox Protein Hox-1G, HOX1G)

Description:
Homeobox containing genes are a family of transcription factors regulating normal development and controlling primary cellular processes like cell identity, cell division and differentiation. The HOXA9 gene encodes a class I homeodomain protein which is involved in hematopoesis and myeloid differentiation. It shows different splice variants like a 1.8-kb homeobox-containing transcript in fetal brain, lung, liver, and kidney, and 2.2- and 3.3-kb transcripts in fetal and adult kidney and in adult skeletal muscle. Fusion between the HOXA9 gene and the nucleoporin gene NUP98, a member of the GLFG nucleoporin family, on 11p15 occurs as a consequence of leukemia-associated chromosomal translocations. So NUP98-HOXA9 is associated with the t(7;11)(p15;p15) translocation in acute myeloid leukemia, myelodysplastic syndrome, and blastic crisis of chronic myeloid leukemia.

Applications:
Suitable for use in Western Blot. Other applications not tested.

Recommended Dilution:
Western Blot: 1-3ug/ml
Optimal dilutions to be determined by the researcher.

Positive Control:
Kidney

Storage and Stability:
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Type	Isotype	Clone	Grade
Pab	IgG		Affinity Purified

Size		Storage	Shipping	Source	Host
100ug		-20°C	Blue Ice	Human	Rabbit

Concentration:

~0.5mg/ml

Immunogen:

Synthetic peptide corresponding to aa225-272 of human HOXA9.

Purity:

Purified by Protein A affinity chromatography.

Form

Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide.

Specificity:

Recognizes human Homeobox protein A9/HOXA9. Species Crossreactivity: chicken, feline, mouse, rat, rhesus monkey. Species sequence homology: xenopus, zebrafish.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

1. Moore, MA. et al. Annals of New York Academy of Science. 1106:114-142 (2007). 2. Popovic, R. et al. Blood Cells Molecules and Diseases. 40:156-159 (2008). 3. Cantile, M. et al. Nutrition Metabolism and Cardiovascular diseases. 18:651-658 (2008).