Technical Data
H7022-90
HOXA9 (Homeobox Protein Hox-A9, Homeobox Protein Hox-1G, HOX1G)
Description:
Homeobox containing genes are a family of transcription factors regulating normal development and controlling primary cellular processes like cell identity, cell division and differentiation. The HOXA9 gene encodes a class I homeodomain protein which is involved in hematopoesis and myeloid differentiation. It shows different splice variants like a 1.8-kb homeobox-containing transcript in fetal brain, lung, liver, and kidney, and 2.2- and 3.3-kb transcripts in fetal and adult kidney and in adult skeletal muscle. Fusion between the HOXA9 gene and the nucleoporin gene NUP98, a member of the GLFG nucleoporin family, on 11p15 occurs as a consequence of leukemia-associated chromosomal translocations. So NUP98-HOXA9 is associated with the t(7;11)(p15;p15) translocation in acute myeloid leukemia, myelodysplastic syndrome, and blastic crisis of chronic myeloid leukemia.

Applications:
Suitable for use in Western Blot. Other applications not tested.

Recommended Dilution:
Western Blot: 1-3ug/ml
Optimal dilutions to be determined by the researcher.

Positive Control:
Kidney

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
PabIgGAffinity Purified
SizeStorageShippingSourceHost
100ug-20CBlue IceHumanRabbit
Concentration:
~0.5mg/ml
Immunogen:
Synthetic peptide corresponding to aa225-272 of human HOXA9.
Purity:
Purified by Protein A affinity chromatography.
Form
Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide.
Specificity:
Recognizes human Homeobox protein A9/HOXA9. Species Crossreactivity: chicken, feline, mouse, rat, rhesus monkey. Species sequence homology: xenopus, zebrafish.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1. Moore, MA. et al. Annals of New York Academy of Science. 1106:114-142 (2007). 2. Popovic, R. et al. Blood Cells Molecules and Diseases. 40:156-159 (2008). 3. Cantile, M. et al. Nutrition Metabolism and Cardiovascular diseases. 18:651-658 (2008).