Technical Data
I0650-04A
ICOSLG (ICOS Ligand, B7 Homolog 2, B7-H2, B7-like Protein Gl50, B7-related Protein 1, B7RP-1, CD275, B7H2, B7RP1, ICOSL, KIAA0653)
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Technical Data |
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I0650-04A |
ICOSLG (ICOS Ligand, B7 Homolog 2, B7-H2, B7-like Protein Gl50, B7-related Protein 1, B7RP-1, CD275, B7H2, B7RP1, ICOSL, KIAA0653) |
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Description: B7-H2 is detected on the surface of monocyte derived immature dendritic cells. It is a putative ligand for ICOS (inducible costimulator) from CD28 family of T cell-costimulators. Costimulatory interactions between the B7 family ligands and their receptors like CD28, CTLA-4 and ICOS play critical role in the growth, differentiation and death of T cells. B7-H2 has four conserved structural cysteins in its extracellular domain which are believed to form the Ig V like and IgC-like domain. In addition, B7-H2 has a conserved tyrosine residue in the Ig V-like domain at position of aa80. B7-H2 shares ~46% homology at aa level to B7h/B7RP-1, a recently described B7 like protein of mouse origin. Applications: Suitable for use in Flow Cytometry, ELISA, Immunoprecipitation and Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry (Formalin fixed paraffin embedded): 1:50 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. |
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