		Technical Data
I7661-09J	Insulin-Like Growth Factor I, Recombinant, Human (IGF1)	100ug 500ug

Growth Factors, Cytokines

Storage: -20°CShipping: Blue Ice

The Insulin-like growth factor-1 (IGF-1) is mitogenic polypeptide growth factors that stimulate the proliferation and survival of various cell types including muscle, bone, and cartilage tissue in vitro. IGF-1 is predominantly produced by the liver, although a variety of tissues produce the IGFs at distinctive times. The IGF-1 belongs to the insulin gene family, which also contains insulin and relaxin. The IGF-1 is similar by structure and function to insulin, but have a much higher growth-promoting activity than insulin. This recombinant human IGF-I is globular protein containing 71 amino acids, and 3 intra-molecular disulfide bonds. Recombinant IGF-1 was expressed in E. coli.

AA Sequence:
MGPETLCGAE LVDALQFVCG DRGFYFNKPT GYGSSSRRAP QTGIVDECCF RSCDLRRLEM YCAPLKPAKS A

Storage and Stability:
May be stored at 4°C for short-term only. For long-term storage, Aliquot and store at -20°C. Aliquots are stable for at least 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Molecular Weight:
7.7kD

Source: Recombinant, Human, (E. coli)
Purity: 95% by SDS-PAGE. Purified by conventional chromatography, after refolding of the isolated inclusion bodies in a renaturation buffer.
Concentration: ~1mg/ml
Form: Supplied as a liquid in PBS, pH 7.4.

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

1. Rinderknecht, E., et al., J. Biol. Chem. 253: 2769 (1978). 2. Zumstein, P., et al., J. Biol. Chem. 262: 11,252 (1987). 3. Rabinovsky, E.D., Neurol. Res. 26: 204-210 (2004).

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.