Technical Data
I7661-44A
Integrin beta6
Description:
Integrins are a large family of transmembrane proteins composed of an alpha and beta component. Integrins are involved in a diversity of biological functions such as cell adhesion, structure, differentiation, apoptosis and cell proliferation. They are the principal cell surface receptors that recognise cell to matrix interactions but little is known about the expression of beta 1 integrin family on airway smooth muscle (ASM) and their involvement in proliferation. This is a contributing factor in structural changes seen in asthma.

Applications:
Suitable for use in Flow Cytometry, Immunoprecipitation, Immunohistochemistry and Immunocytochemistry. Not suitable for use in Function Blocking or Western Blot. Other applications not tested.

Recommended Dilutions:
Immunoprecipitation: Because I7661-44A is an IgG2a, protein G or rabbit anti-mouse IgG is helpful for capture.
Immunohistochemistry(IC): Acetone fix. Nuclear background staining limits usefulness in these techniques.
Otimal dilution to be determined by researcher.

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
MabIgG2a2Q791Affinity Purified
SizeStorageShippingSourceHost
100ug-20CBlue IceHumanMouse
Concentration:
~1mg/ml
Immunogen:
Murine NIH 3T3 cells stably transfected with the human b6 subunit.
Purity:
Purified by affinity chromatography.
Form
Supplied as a liquid in PBS. No preservatives added.
Specificity:
Recognizes human Integrin beta6.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1. Weinaker, et al., J. Biol. Chem. 269: 6940 (1994).