		Technical Data
I8439-04P	Interleukin 17 (IL-17, CTLA8, IL-17A, Interleukin-17A Precursor, Cytotoxic T-lymphocyte-associated Antigen 8)

Description:
Mouse interleukin-17 (IL-17/IL-17A), a disulfide-linked homodimer and member of the IL-17
family, secreted primarily by activated CD4+ T cells, which signals through the IL-17 receptor (IL-17R). IL-17 induces a variety of target cells to secrete inflammatory cytokines, including IL-1beta, IL-6, TNFalpha, IFNgamma and granulocyte colony-stimulating factor, as well as synergizing with other inflammatory cytokines and agonists. Increased levels of IL-17 are detectable during transplant rejection, and also during rheumatoid arthritis, possibly contributing to bone destruction.

Applications:
Suitable for use in ELISA and Western Blot. Other applications not tested.

Recommended Dilution:
ELISA: 0.5-2ug/ml
Western Blot: 0.1-0.2ug/ml
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile 40-50% glycerol, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Type	Isotype	Clone	Grade
Pab	IgG		Affinity Purified

Size		Storage	Shipping	Source	Host
100ug		4°C/-20°C (No Glycerol)	Blue Ice	Mouse	Rabbit

Concentration:

Not determined

Immunogen:

Recombinant mouse IL-17.

Purity:

Purified by immunoaffinity chromatography.

Form

Supplied as a lyophilized powder from PBS, pH. 7.2. No preservative added. Reconstitute with 100ul sterile 40-50% glycerol, ddH2O.

Specificity:

Recognizes mouse Interleukin 17.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.