Technical Data
I8439-35H
Interleukin-17 Receptor A (IL17RA, IL-17RA, CDw217, CD217, MGC10262, AW538159) (APC)
Description:
Interleukin-17 is a pleotropic cytokine expressed by T cells. IL-17 binds to the IL-17 receptor (IL-17 R), which shares no homology with any other known family of receptors. While the expression of IL-17 is restricted to activated T cells, the IL-17 R mRNA exhibits a broad tissue distribution, and has been detected in virtually all cells and tissues tested. The aa sequence of mouse IL-17 R is 69% identical to human IL-17 R. The signaling events mediated by IL-17 include activation of NF-KB and JNK, and require TNF receptor-associated factor 6 (TRAF6) in the signaling pathway.

Applications:
Suitable for use in Flow Cytometry. Other applications not tested.

Recommended Dilutions:
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4C before opening. DO NOT FREEZE! Stable at 4C as an undiluted liquid. Dilute only prior to immediate use. Stable for 12 months. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer. Freezing Allophycocyanin (APC) conjugates will result in a substantial loss of activity. Allophycocyanin (APC) conjugates are sensitive to light.
TypeIsotypeCloneGrade
MabIgG2a12K116Affinity Purified
SizeStorageShippingSourceHost
100Tests4C Do Not FreezeBlue IceMouseRat
Concentration:
~0.025mg/ml
Immunogen:
Recombinant protein corresponding to aa32-322 from the extracellular domain of mouse IL-17 R expressed in NSO cell line.
Purity:
Purified by Protein G affinity chromatography.
Form
Supplied as a liquid in saline, 0.5% BSA, 0.1% sodium azide. Labeled with Allophycocyanin (APC).
Specificity:
Recognizes mouse IL-17 R.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1. Yao, Z. et al. (1997) Cytokine 9:794. 2. Schwander, R. et al. (2000) J. Exp. Med. 191:1233.