		Technical Data
I8443-49G	IL-23 Receptor (IL-23R, IL-23 Receptor, IL23R)

Description:
Recently, IL-23 is a heterodimeric cytokine that shares biological properties with proinflammatory cytokines has been discovered. IL-23 is composed of the IL-12p40 soluble receptor subunit and a novel cytokine-like subunit related to IL-12p35, termed p19. IL-23 mediates it cellular function by binding to IL-23 receptor (IL-23R), which pairs with IL-12Rb1 to confer IL-23 responsiveness. However, human IL-12 does not bind to human IL-23R. IL-23 has been shown to possess biological activities on T cells that are similar as well distinct from those of IL-12.

Applications:
Suitable for use in Western Blot, Immunohistochemistry. Other applications not tested.

Recommended Dilution:
Western Blot: 0.1-1ug/ml
Immunohistochemistry (formalin fixed paraffin embedded): 5-10ug/ml
Optimal dilutions to be determined by the researcher.

Positive Control:
Jurkat, NIH3T3

Storage and Stability:
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Type	Isotype	Clone	Grade
Pab	IgG		Affinity Purified

Size		Storage	Shipping	Source	Host
200ul		-20°C	Blue Ice	Human	Rabbit

Concentration:

~0.5mg/ml

Immunogen:

Synthetic peptide corresponding to aa439-455 (EIFIPEHKPTDYKKENT) of human IL-23 receptor, Genbank no NP_653302.

Purity:

Purified by Protein G affinity chromatography.

Form

Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide.

Specificity:

Recognizes human IL-23R. Species Crossreactivity: mouse.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

1. Parham C, Chirica M, Timans J, et al. Immunol. 168(11): 5699-708 (2002). 2. Belladonna ML, Renauld JC, Bianchi R, et al. J Immunol. 168 (11): 5448-5454 (2002). 3. Watford WT, Hissong BD, Bream JH, et al. Immunol Rev. 202:139-156 (2004).