Technical Data
I8443-49G
IL-23 Receptor (IL-23R, IL-23 Receptor, IL23R)
Description:
Recently, IL-23 is a heterodimeric cytokine that shares biological properties with proinflammatory cytokines has been discovered. IL-23 is composed of the IL-12p40 soluble receptor subunit and a novel cytokine-like subunit related to IL-12p35, termed p19. IL-23 mediates it cellular function by binding to IL-23 receptor (IL-23R), which pairs with IL-12Rb1 to confer IL-23 responsiveness. However, human IL-12 does not bind to human IL-23R. IL-23 has been shown to possess biological activities on T cells that are similar as well distinct from those of IL-12.

Applications:
Suitable for use in Western Blot, Immunohistochemistry. Other applications not tested.

Recommended Dilution:
Western Blot: 0.1-1ug/ml
Immunohistochemistry (formalin fixed paraffin embedded): 5-10ug/ml
Optimal dilutions to be determined by the researcher.

Positive Control:
Jurkat, NIH3T3

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
PabIgGAffinity Purified
SizeStorageShippingSourceHost
200ul-20CBlue IceHumanRabbit
Concentration:
~0.5mg/ml
Immunogen:
Synthetic peptide corresponding to aa439-455 (EIFIPEHKPTDYKKENT) of human IL-23 receptor, Genbank no NP_653302.
Purity:
Purified by Protein G affinity chromatography.
Form
Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide.
Specificity:
Recognizes human IL-23R. Species Crossreactivity: mouse.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1. Parham C, Chirica M, Timans J, et al. Immunol. 168(11): 5699-708 (2002). 2. Belladonna ML, Renauld JC, Bianchi R, et al. J Immunol. 168 (11): 5448-5454 (2002). 3. Watford WT, Hissong BD, Bream JH, et al. Immunol Rev. 202:139-156 (2004).