Technical Data
JK 184 (N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)-2-thiazolamine)
Biochemicals Storage: -20CShipping: Blue Ice
An imidazopyridine derivative that acts as a potent downstream antagonist of Hedgehog(Hh) signaling pathway. JK184 functions by inhibiting class IV alcohol dehydrogenase (Aldh7) (IC50 = 210 nM).

Storage and Stability:
Lyophilized powder may be stored at -20C. Stable for 12 months at -20C. Reconstitute with DMSO or ethanol. Aliquot to avoid repeated freezing and thawing. Store at -20C. Reconstituted product is stable for 6 months at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer

CAS Number:

Molecular Formula:

Molecular Weight:
Purity: ~98% (HPLC)
Form: Supplied as a beige solid. Reconstitute with 100mM DMSO and 25mM ethanol.

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
01., T., et al. (2009). Angew. Chem. Int. Ed.Engl. 48, 2321-2324; 2. Lee, J., et al. (2007). Chembiochem 8, 1916- 1919.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.