Technical Data
J1299-25
JK 184 (N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)-2-thiazolamine)
1mg
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Technical Data |
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J1299-25 |
JK 184 (N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)-2-thiazolamine) |
1mg |
| Biochemicals | Storage: -20°CShipping: Blue Ice |
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An imidazopyridine derivative that acts as a potent downstream antagonist of Hedgehog(Hh) signaling pathway. JK184 functions by inhibiting class IV alcohol dehydrogenase (Aldh7) (IC50 = 210 nM). Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with DMSO or ethanol. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer CAS Number: 315703-52-7 Molecular Formula: C19H18N4OS Molecular Weight: 350.44 |
Purity: ~98% (HPLC) Form: Supplied as a beige solid. Reconstitute with 100mM DMSO and 25mM ethanol. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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01., T., et al. (2009). Angew. Chem. Int. Ed.Engl. 48, 2321-2324; 2. Lee, J., et al. (2007). Chembiochem 8, 1916- 1919.
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