Technical Data
J8025-03B
Junctional Adhesion Molecule C (JAMC, JAM-C, FLJ14529, Junctional Adhesion Molecule 3, JAM3, JAM-3, UNQ859/PRO1868)
Description:
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is localized in the tight junctions between high endothelial cells. Unlike other proteins in this family, the this protein is unable to adhere to leukocyte cell lines and only forms weak homotypic interactions. The encoded protein is a member of the junctional adhesion molecule protein family and acts as a receptor for another member of this family.

Applications:
Suitable for use in ELISA. Other applications have not been tested.

Recommended Dilutions:
Peptide ELISA Titer: 1:
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
PabIgGAffinity Purified
SizeStorageShippingSourceHost
100ug-20CBlue IceHumanGoat
Concentration:
~0.5mg/ml
Immunogen:
Synthetic peptide corresponding to C-KQDGESYKNPGKPD, from the internal region (near C-Terminus) of human JAM3 (NP_116190.2)
Purity:
Purified by peptide affinity chromatography.
Form
Supplied as a liquid in Tris saline, pH 7.3, 0.5% BSA, 0.02% sodium azide.
Specificity:
Recognizes JAM3. Species sequence homology: human, bovine.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1. Ueki T, Iwasawa K, Ishikawa H, Sawa Y, Expression of junctional adhesion molecules on the human lymphatic endothelium. Microvascular research 2008 Mar 75 (2): 269-78. PMID: 17822725