Technical Data
K0005-14H
Kallikrein 11 (KLK11, Hippostasin, Protease Serine 20 Trypsin-like, PRSS20, Trypsin-like Serine Protease, TLSP)
Description:
Hippostatin, also known as KLK11, is a kallikrein-like serine protease, which has two alternatively spliced isoforms, brain-type and prostate-type. Hippostatin plays a role in the prostate, including reproductive and/or tumorigenic functions. Elevated serum levels of hK11 were found in 70% of women with ovarian cancer and in 60% of men with prostate cancer. Analysis of the KLK11 biomarker in serum may aid in the diagnosis and monitoring of ovarian and prostatic carcinoma.

Applications:
Suitable for use in Western Blot. Other applications not tested.

Recommended Dilution:
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20C. Aliquots are stable for at least 12 months at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
TypeIsotypeCloneGrade
PabAffinity Purified
SizeStorageShippingSourceHost
100ul-20CBlue IceHumanRabbit
Concentration:
~1mg/ml
Immunogen:
Residues 68-82 [YIVHLGQHNLQKEEG] of the 35 kDa human hippostasin/KLK11protein. Sequence identity to mouse and rat: 86%.
Purity:
Purified by immunoaffinity chromatography.
Form
As reported
Specificity:
This antibody is specific for Hippostatin/KLK11.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1. Diamandis,E.P. et al. Cancer Res. 62 (1), 295-300 (2002).
2. Nakamura,T et al. Prostate. 54(4), 299-305 (2003).