		Technical Data
K0005-14H	Kallikrein 11 (KLK11, Hippostasin, Protease Serine 20 Trypsin-like, PRSS20, Trypsin-like Serine Protease, TLSP)

Description:
Hippostatin, also known as KLK11, is a kallikrein-like serine protease, which has two alternatively spliced isoforms, brain-type and prostate-type. Hippostatin plays a role in the prostate, including reproductive and/or tumorigenic functions. Elevated serum levels of hK11 were found in 70% of women with ovarian cancer and in 60% of men with prostate cancer. Analysis of the KLK11 biomarker in serum may aid in the diagnosis and monitoring of ovarian and prostatic carcinoma.

Applications:
Suitable for use in Western Blot. Other applications not tested.

Recommended Dilution:
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Type	Isotype	Clone	Grade
Pab			Affinity Purified

Size		Storage	Shipping	Source	Host
100ul		-20°C	Blue Ice	Human	Rabbit

Concentration:

~1mg/ml

Immunogen:

Residues 68-82 [YIVHLGQHNLQKEEG] of the 35 kDa human hippostasin/KLK11protein. Sequence identity to mouse and rat: 86%.

Purity:

Purified by immunoaffinity chromatography.

Form

As reported

Specificity:

This antibody is specific for Hippostatin/KLK11.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

1. Diamandis,E.P. et al. Cancer Res. 62 (1), 295-300 (2002).
2. Nakamura,T et al. Prostate. 54(4), 299-305 (2003).