Technical Data
LOXL2 (Lysyl Oxidase-like Protein 2, Lysyl Oxidase Related Protein 2, LOR2, Lysyl Oxidase Homolog 2, Lysyl Oxidase Related Protein WS9-14)
Lysyl Oxidase (LO) is an extracellular, copper-dependent enzyme that initiates the cross-linking of collagens and elastin by catalyzing the oxidative deamination of peptidyl lysine to alpha-aminoadipic-delta-semialdehyde. Members of LO family have diverse functions which include tumor suppression and cell adhesion and senescence. LOXL2, a 87kD protein, is a novel member of this family. It contains 3 potential N-linked glycosylation sites, 4 scavenger receptor cysteine-rich (SRCR) domains and highly conserved copper-binding and Lysyl-tyrosylquinone cofactor sites. It is a component of extracellular matrix that might be involved in cell adhesion and senescence. Role of LOXL2 has been implicated in malignant transformation.

Suitable for use in ELISA. Other applications not tested.

Recommended Dilution:
ELISA: 1:100-1:1000
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
PabIgGAffinity Purified
100ug-20CBlue IceHumanRabbit
Synthetic peptide corresponding to aa61-73 (AGQKRKHSEGRVE) of human LOXL2.
Purified by Protein G affinity chromatography.
Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide.
Recognizes human LOXL2. Species Crossreactivity: chimpanzee, canine, bovine. Species sequence homology: mouse, rat, chicken.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1. Saito,H., Papaconstantinou,J., Sato,H. and Goldstein,S. Regulation of a novel gene encoding a lysyl oxidase-related protein in cellular adhesion and senescence. J. Biol. Chem. 272 (13), 8157-8160 (1997). 2. Jourdan-Le Saux,C., Tronecker,H., Bogic,L., Bryant-Greenwood,G.D., Boyd,C.D. and Csiszar,K. The LOXL2 gene encodes a new lysyl oxidase-like protein and is expressed at high levels in reproductive tissue. J. Biol. Chem. 274 (18), 12939-12944 (1999). 3. Molnar,J., Fong,K.S., He,Q.P., Hayashi,K., Kim,Y., Fong,S.F., Fogelgren,B., Szauter,K.M., Mink,M. and Csiszar,K. Structural and functional diversity of lysyl oxidase and the LOX-like proteins. Biochim. Biophys. Acta 1647 (1-2), 220-224 (2003).