Technical Data
L3010-19B
Lithostathine-1-alpha (REG1A, Islet Cells Regeneration Factor, ICRF, Islet of Langerhans Regenerating Protein, REG, Pancreatic Stone Protein, PSP, Pancreatic Thread Protein, PTP, Regenerating Islet-derived Protein 1-alpha, REG-1-alpha, Regenerating Protei
Description:
Reg1A, also known as PTP, PSP, and lithostathine, is a member of the Reg family of secreted proteins with a C-type lectin domain. Due to variable glycosylation, pancreatic Reg1A exists as multiple species of 16-18kD. Reg1A promotes the maintenance and growth of pancreatic islet B cells and intestinal villi. It is upregulated in pancreatitis and some carcinomas. Reg1A is an antigenic target in autoimmune diabetes. Human Reg1A shares 65%-68% aa identity with mouse and rat Reg1A.

Applications:
Suitable for use in Flow Cytometry. Other applications not tested.

Recommended Dilution:
Optimal dilutions to be determined by the researcher.

Excitation: 620-650nm

Emission: 660-670nm

Storage and Stability:
May be stored at 4°C before opening. DO NOT FREEZE! Stable at 4°C as an undiluted liquid. Dilute only prior to immediate use. Stable for 12 months. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer. APC is light sensitive.
TypeIsotypeCloneGrade
MabIgG2B12K128Affinity Purified
SizeStorageShippingSourceHost
100 Tests4°C Do Not FreezeBlue IceHumanRat
Concentration:
Not determined
Immunogen:
Recombinant corresponding to aa23-166 from human Reg1A expressed in E.coli.
Purity:
Purified by Protein G affinity chromatography.
Form
Supplied as a liquid in saline, 0.5% BSA, 0.1% sodium azide. Labeled with Allophycocyanin (APC).
Specificity:
Recognizes human Reg1A.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.