Technical Data
L4500-06A
LRP, MVP (Lung-resistance Related Protein, Major Vault Protein, 2310009M24Rik, VAULT1)
Description:
MVP is identical to Lung-Resistance Related Protein (LRP). Treatment of cells with estradiol increases the amount of MVP in nuclear extract. Antibodies to progesterone and glucocorticoid receptors are also able to co-immunoprecipitate the MVP.

Cellular Localization: Cytoplasmic, 5% are nucleus associated and localize to the nuclear pore complexes

Applications:
Suitable for use in Western Blot, Immunoprecipitation and Immunohistochemistry. Other applications not tested.

Recommended Dilution:
Immunohistochemistry: 1:50-1:100.
Optimal dilutions to be determined by the researcher.

Storage and Stability:

May be stored at 4C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20C. Aliquots are stable for at least 12 months at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
TypeIsotypeCloneGrade
MabIgG18L602Purified
SizeStorageShippingSourceHost
500ul-20CBlue IceHumanMouse
Concentration:
Not determined
Immunogen:
Proteins precipitated with AER317 from the phosphocellulose column flow through of extract of human breast cancer MCF-7 cells.
Purity:
Purified
Form
Supplied as a liquid in PBS, pH 7.2.
Specificity:
This antibody reacts with a 104 to 110kD protein known as Major Vault Protein (MVP). Species Crossreactivity: Crossreacts with Human and Rat.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
Abbondanza C et al. Interaction of vault particles with estrogen receptor in the MCF-7 breast cancer cell. J Cell Biol 141:1301-10 (1998).