Technical Data
Ly6K (Lymphocyte Antigen 6K, Ly-6K, CO16)
Ly-6 antigens are a group of highly homologous, GPI anchored surface proteins which might have a role in cell adhesion and signaling in Keratinocytes. These proteins are highly expressed in several cancers including HNSCC. Ly-6K has been identified as a novel member of this family using comprehensive gene-screening and expression analysis. It is a human homolog of murine ly-6K and is located on chromosome 8q24. It consists of 10 conserved cysteine residues and harbors a sequence that theoretically determines GPI anchoring. It is selectively expressed in HNSCC and normal squamous cells. Its expression has also been observed in HNSCC cell lines devoid of E48 antigen. Ly-6K can be further evaluated as a target antigen for HNSCC diagnosis and therapy.

Suitable for use in Western Blot, ELISA and Immunohistochemistry. Other applications not tested.

Recommended Dilution:
ELISA: 1:100-1:2000
Immunohistochemistry: paraffin sections
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
PabIgGAffinity Purified
100ug-20CBlue IceHumanRabbit
Synthetic peptide corresponding to aa82-100, RQRDPEDSQRTDEGDNRVW, from human Ly-6K (NP_059997.2).
Purified by Immunoaffinity chromatography.
Supplied as a liquid in PBS, 0.02% sodium azide.
Recognizes human Ly-6K.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1. Arnolda Int. J. Cancer: 103, 768774 (2003).