		Technical Data
M1202-04B	Macrophage Inflammatory Protein 1 alpha, Recombinant, Human (CCL3, Chemokine (C-C Motif) Ligand 3, G0/G1 Switch Regulatory Protein 19-1, G0S19-1, G0S19-1 Protein, LD78ALPHA, MIP1A, MIP-1-alpha, PAT 464.1, SCYA3, SIS-beta, Small Inducible Cytokine A3 Precu	10ug

Growth Factors, Cytokines

Storage: -70°CShipping: Dry Ice

Macrophage Inflammatory Protein-1 (MIP-1,alpha) is part of the CC subfamily of the chemokine superfamily of chemoattractant cytokines. MIP-1& alpha affects the inflammatory response of blood monocytes, tissue macrophages, and T cells. MIP-1,alpha also enhances the formation of granulocyte-macrophage colonies stimulated by GM-CSF or M-CSF. Human MIP-1,alpha is composed of 69 aa residues with not possible N-linked glycosylation sites, and several possible O-linked sites. Human MIP-1,alpha is 60% homologous with human MIP-1, alpha, 75% homologous with murine MIP-1,alpha, and has been shown to be active on murine cells.

Biological Activity:
The biological activity of recombinant human MIP-1 alpha is determined by its use as a cofactor for CSF-dependent myelopoiesis.

Storage and Stability:
For long-term storage, aliquot to avoid repeated freezing and thawing and freeze at -70°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquots are stable for 6 months.

Molecular Weight:
8kD

Source: yeast
Purity: Purified by seuential chromatography. 95% pure by SDS gel electrophoresis with low endotoxin.
Concentration: ~1mg/ml
Form: Supplied as a liquid in sterile dH2O.

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

1Nathan, C.F. (1987)J. Clin. Invest. 79:319 2. Wolpe S.D. et al. (1989) Proc. Natl. Acad. Sci. (USA) 86:612 3. Tekamp-Olson. P. et al. (1990) J. Exp. Med. 172:911 2. Dunlop, et al (1992) Blood 79: 2221
3. Suzuki, K. et al. (1989) J. Exp. Med. 169:1895

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.