Technical Data
Macrophage Inflammatory Protein 2-alpha, Recombinant, Human (CXCL2, Chemokine (C-X-C Motif) Ligand 2, CINC-2a, GRO2, GROb, GROB, Gro-beta, Growth-regulated Protein beta, Macrophage Inflammatory Protein 2-alpha Precursor, MGSA-b, MGSA beta, MIP2, MIP2A, MI
Growth Factors, Cytokines Storage: -70CShipping: Blue Ice
Chemokine (C-X-C motif) ligand 2 (CXCL2) is a small cytokine belonging to the CXC chemokine family that is also called macrophage inflammatory protein 2-alpha (MIP2-alpha), Growth-regulated protein beta (Gro-beta) and Gro oncogene-2 (Gro-2). CXCL2 is 90% identical in amino acid sequence as a related chemokine, CXCL1. This chemokine is secreted by monocytes and macrophages and is chemotactic for polymorphonuclear leukocytes and hematopoietic stem cells. The gene for CXCL2 is located on human chromosome 4 in a cluster of other CXC chemokines.[CXCL2 mobilizes cells by interacting with a cell surface chemokine receptor called CXCR2.


Biological Activity:
The biological activity of recombinant human MIP-2&# alpha is determined by its use as a cofactor for CSF-dependent myelopoiesis.

Storage and Stability:
Lyophilized powder may be stored at -20C. Reconstitute to with sterile dH2O or buffer, aliquot and store at -20C. Reconstituted product is stable for 6 months at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Source: yeast
Purity: Purified. 95% pure by SDS gel electrophoresis.
Concentration: As reported
Form: Supplied as a lyophilized powder in PBS, 20mM HEPES/0.1M NaCl ph7.3

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
1. Nathan, C.F. (1987)J. Clin. Invest. 79:31 2. Tekamp-Olson. P. et al. (1990) J. Exp. Med. 172:911 3. Wolpe S.D. et al. (1989) Proc. Natl. Acad. Sci. (USA) 86:612

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.