Technical Data
M4688-33
MRP7 (Multidrug Resistance-associated Protein 7, ATP-binding Cassette Sub-family C Member 10, ABCC10, EST182763, SIMRP7)
Description:
Applications:
Suitable for use in Western Blot, Immunohistochemistry and Immunocytochemistry. Other applications not tested.

Recommended Dilutions:
Western Blot: 1:20-1:50
Immunohistochemistry (Acetone fixed frozen): 1:20
Immunocytochemistry (Acetone fixed): 1:20-1:50
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
MabIgGM7I-3Supernatant
SizeStorageShippingSourceHost
1ml-20CBlue IceHumanRat
Concentration:
Not Determined
Immunogen:
Bacterial fusion protein of human MRP7, aa194-272.
Purity:
Supernatant
Form
Supplied as a liquid in 0.7% BSA, 0.1% sodium azide.
Specificity:
Recognizes an internal epitope of human MRP7 (ABCC10) at ~160kD.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1. Imatinib and nilotinib reverse multidrug resistance in cancer cells by inhibiting the efflux activity of the MRP7 (ABCC10). Shen T, Kuang YH, Ashby CR, Lei Y, Chen A, Zhou Y, Chen X, Tiwari AK, opper-Borge E, Ouyang J, Chen ZS. PLoS One. 2009 Oct 20;4(10) 2. Human multidrug resistance protein 7 (ABCC10) is a resistance factor for nucleoside analogues and epothilone B. Hopper-Borge E, Xu X, Shen T, Shi Z, Chen ZS, Kruh GD. Cancer Res. 2009 Jan 1;69(1):178-84. 3. ABCC10/MRP7 is associated with vinorelbine resistance in non-small cell lung cancer. Bessho Y, Oguri T, Ozasa H, Uemura T, Sakamoto H, Miyazaki M, Maeno K, Sato S, Ueda R. Oncol Rep. 2009 Jan;21(1):263-8. 4. Analysis of the drug resistance profile of multidrug resistance protein 7 (ABCC10): resistance to docetaxel. Hopper-Borge E, Chen ZS, Shchaveleva I, Belinsky MG, Kruh GD. Cancer Res. 2004 Jul 15;64(14):4927-30.