Technical Data
N1193-18
Netrin-4 (PRO3091, NTN4, FLJ23180, Beta-netrin)
Description:
Netrin-4 is a 628 amino acid laminin-related secreted protein that promotes neurite elongation at low concentrations but inhibits neurite extension at high concentrations. Recent evidence suggest that Netrin family members act as regulators of both neuronal and vascular growth and are implicated in controling epithelial cell branching morphogenesis in the pancreas, breast and lung. Netrin-4 inhibits proliferation of a variety of human tumor cells. Netrin-4 also induces proliferation, migration, adhesion, tube formation and survival of human lymphatic endothelial cells and seems to function as a lymphangiogenic factor contributing to tumor dissemination.

Applications:
Suitable for use in ELISA. Other applications not tested.

Recommended Dilution:
ELISA: 1:32000
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
PabAffinity Purified
SizeStorageShippingSourceHost
100ug-20CBlue IceGoat
Concentration:
~0.5mg/ml
Immunogen:
Synthetic peptide corresponding to SENTDLTCRQPK, aa65-76 of NTN4.
Purity:
Purified by immunoaffinity chromatography.
Form
Supplied as a liquid in tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.
Specificity:
Recognizes NTN4. Species sequence homology: Human, mouse, caninie and bovine.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1. Sokolowski M, Wasserman J, Wasserman D. Association of polymorphisms in the SLIT2 axonal guidance gene with anger in suicide attempters. Molecular psychiatry 2010 Jan 15 (1): 10-1.