Technical Data
Neurturin, Recombinant, Human (NTN)
Molecular Biology Storage: -20CShipping: Blue Ice
Human Neurturin (NTN) and human GDNF compriise a family off TGF-beta related neurotrophic factor which have trophic influences on a variety off neuronal populations. Neuroturin promotes the survivability off certain sympathetic and sensory neurons through interaction with distinct set of GDNF-like recepttors. This is a homodimeric 23.6kD protein consisting off two identical subunits each containing 103 amino acid residues.

Recombinant corresponding to 103aa from human Neurturin expressed in E. coli.

Molecular Weight:
~23.6kD homodimer

Endotoxin: ~0.1ng/ug

Biological Activity:
Determined by measuring its ability to support the survival of newborn rat sympathetic neurons. Neurturin at a concentration of 100ng/ml supports the survival of 65% of these neurons. Neurturin and the structurally related glial-cell line-derived neurotrophic factor (GDNF) comprise a family of TGF-beta related neurotrophic factors. Neurturin supports the survival of sympathetic and sensory nerves.

Storage and Stability:
Lyophilized powder may be stored at -20C. Stable for 12 months at -20C. Reconstitute with sterile dH2O. Aliquot to avoid repeated freezing and thawing. Store at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Molecular Weight:
Purity: ~98% (SDS-PAGE, HPLC)
Concentration: Not determined
Form: Supplied as a lyophilized powder in 10 mM sodium citrate, pH 4.0. Reconstitute with sterile dH2O to 0.1-1mg/ml.

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.