Okadaic Acid, Sodium salt (Halochondrine A)
|Biochemicals||Storage: -20°CShipping: Blue Ice|
Okadaic Acid, a marine toxin, polyether derivative produced by dinoflagellates, is a potent, cell-permeable, specific inhibitor of PP-1 and PP-2 serine/threonine-speci c protein phosphatases in a variety of cell types. Salt form of okadaic acid, with somewhat greater stability than the free acid when stored in organic solvents.
Source: Prorocentrum concavum
Solubility: Soluble in DMSO or ethanol.
Storage and Stability:
Light Sensitive. Store at -20°C. Stable as a powder for at least 12 months. Stable as a liquid for 6 months.
WARNING: Highly irritant to skin and mucous membranes.
SPECIAL HAZARD: TUMOR PROMOTER. Gloves and mask should be worn when using this compound. Care must be taken to prevent contact through all routes of exposure.
Source: Prorocentrum concavum
Purity: Purified by preparative flash, medium pressure nad high performance liquid chromatography.
Form: Supplied as white powder.
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
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Takai, J. Mus. Res. & Cell Motil. 9:563, 1988 Wheat et al., Mol. Cell. Biol. 14:5881, 1994
Amara, F. M. et al.: Defining a Novel cis-Element in the 3’-Untranslated Region of Mammalian Ribonucleotide Reductase Component R2 mRNA. J. Biol. Chem. (1996) 271, 20126-20131: Cell culture.
Mimnaugh, E. G. et al.: Possible Role for Serine/Threonine Phosphorylation in the Regulation of the Heteroprotein Complex between the hsp90 Stress Protein and the pp60v-src Tyrosine Kinase. J. Biol. Chem. (1995) 270, 28654-28659: Cell culture.
Wheat, W.H. et al.: Simian virus 40 small tumor antigen inhibits dephosphorylation of protein kinase A-phosphorylated CREB and regulates CREB transcriptional stimulation. Mol. Cell. Biol. (1994) 14, 5881-5890: Inhibitor in protein phosphatase assay.
Trichostatin A (19-138)
El-Osta, A., et. al. Precipitous Release of Methyl-CpG Binding Protein 2 and Histone Deacetylase 1 from the Methylated Human Multidrug Resistance Gene (MDR1) on Activation. Molecular and Cellular Biology (2002) 22: 1844-1857. Chromatin Immunoprecipitation
Calyculin A (19-139)
Gautreau, A., et.al. Morphogenic Effects of Erzin Require a Phosphorylation Induced Transition from Oligomers to Monomers at the Plasma Membrane. The Journal of Cell Biology (2000) 150: 193-204. Serine/Threonine Inhibition
LY 294002 (19-142)
Wei, Q., et. al. Pitx2a Expression Alters Actin-Myosin Cytoskeleton and Migration of HeLa Cells through Rho GTPase Signaling. Mol. Biol. Cell (2002) 13: 683-697.PI3K Inhibition
PD 98059 (19-143)
Wei, Q., et. al. Pitx2a Expression Alters Actin-Myosin Cytoskeleton and Migration of HeLa Cells through Rho GTPase Signaling. Mol. Biol. Cell (2002) 13: 683-697. MEK1 Inhibition