Technical Data
O6154-01
Oligomycin B
5mg
Biochemicals Storage: -20CShipping: Blue Ice
Oligomycin B, a minor component of the oligomycin complex isolated from selected strains of Streptomyces sp., is an inhibitor of mitochondrial F1F0-ATPase. It makes cells more susceptible to cell death and also leads to a switch in the death mode from apoptosis to necrosis.

Related to:
Oligomycin A, Oligomycin C, 21-hydroxyoligomycin A

Solubility:
Soluble in ethanol, methanol, DMF or DMSO.

Storage and Stability:
For long-term storage, aliquot and store at -20C. Aliquots are stable for at least 12 months at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

CAS Number:
11050-94-5

Molecular Formula:
C45H72O12

Molecular Weight:
805.1
Source: Streptomyces sp.
Purity: ~ 95% by HPLC
Form: Supplied as a white solid.

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
1. Age-dependent cell death and the role of ATP in hydrogen peroxide-induced apoptosis and necrosis. Miyoshi N. et al. Proc. Natl Acad. Sci. USA 2006, 103, 1727. 2. Mitochondria in eosinophils: functional role in apoptosis but not respiration. Peachman K.K. et al. Proc. Natl Acad. Sci. USA 2001, 98, 1717. 3. The BH3 domain is required for caspase-independent cell death induced by Bax and oligomycin. Fitch M.E. et al. Cell Death Differ. 2000, 7, 338..

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.