Technical Data
O6154-01
Oligomycin B
5mg
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Technical Data |
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O6154-01 |
Oligomycin B |
5mg |
| Biochemicals | Storage: -20°CShipping: Blue Ice |
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Oligomycin B, a minor component of the oligomycin complex isolated from selected strains of Streptomyces sp., is an inhibitor of mitochondrial F1F0-ATPase. It makes cells more susceptible to cell death and also leads to a switch in the death mode from apoptosis to necrosis. Related to: Oligomycin A, Oligomycin C, 21-hydroxyoligomycin A Solubility: Soluble in ethanol, methanol, DMF or DMSO. Storage and Stability: For long-term storage, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. CAS Number: 11050-94-5 Molecular Formula: C45H72O12 Molecular Weight: 805.1 |
Source: Streptomyces sp. Purity: ~ 95% by HPLC Form: Supplied as a white solid. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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1. Age-dependent cell death and the role of ATP in hydrogen peroxide-induced apoptosis and necrosis. Miyoshi N. et al. Proc. Natl Acad. Sci. USA 2006, 103, 1727. 2. Mitochondria in eosinophils: functional role in apoptosis but not respiration. Peachman K.K. et al. Proc. Natl Acad. Sci. USA 2001, 98, 1717. 3. The BH3 domain is required for caspase-independent cell death induced by Bax and oligomycin. Fitch M.E. et al. Cell Death Differ. 2000, 7, 338..
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