Technical Data
O7030-13
Opioid Receptor, delta, NT
Description:
The function of the delta-opioid receptors has not been determined. However, recent studies in rodents have linked delta-opioid receptor antagonists with prevention of morphine tolerance and dependence without relinquishing mu-opioid antinociception. In general, opioids modulate numerous central and peripheral processes, including pain perception, neuroendocrine secretion and the immune response. The opioid signal is transduced from receptors through G proteins to various different effectors. Subsequent to G protein activation, several effectors are known to orchestrate the opioid signal. For example, activation of opioid receptors increases phosphatidylinositol turnover, activates K+ channels and reduces adenylyl cyclase and Ca++ channel activities.

Applications:
Suitable for use in Immunohistochemistry. Other applications not tested.

Recommended Dilution:
Immunohistochemistry: 1:1000. CNS tissues fixed in PLP. Can be used with paraffin embedded tissue also.
Optimal dilutions to be determined by the researcher.

Control Peptide:
O7030-12: Opioid Receptor, delta, NT, Control Peptide

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
PabIgGSerum
SizeStorageShippingSourceHost
50ul-20CBlue IceMouseRabbit
Concentration:
Not Determined
Immunogen:
Delta opioid receptor N-terminal peptide, LVPSARAELQSSPLV.
Purity:
Serum
Form
Supplied as a liquid.
Specificity:
Recognizes mouse Delta opioid receptor. Species Crossreactivity: rat.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1.Brain Research (1996) 738:181195. 2.J of Comparative Neurology (1997) 381:373387. 3.Persson PA et al J Neuroscience Research (2000) 61:371-375. 4. Varona A et al., Drug Research (2003) 53:21-25. 5. Saland L C. et al., Neuroscience Letters (2005) 381:163-168. 6. Persson A I e t al Neuroscience Research (2005) 52:1-9.